Mary L. Bouxsein, Ph.D.

Assistant Professor of Orthopedic Surgery

Phone: 617.667.4594

Fax:     617.667.7175

Email:  mbouxsei@bidmc.harvard.edu

Background

Dr. Bouxsein received her doctorate in Mechanical Engineering from Stanford University and completed a post-doctoral fellowship at the Orthopedic Biomechanics at Harvard Medical School. She currently holds joint appointments as an Assistant Professor of Orthopedic Surgery at Harvard Medical School, an adjunct Assistant Professor of Mechanical and Aerospace Engineering at Boston University, and Visiting Scientist at the Jackson Laboratory in Bar Harbor, ME. Her research focuses on understanding skeletal fragility from a biomechanics viewpoint, and includes studies using animal models and human cadaveric tissue, as well as clinical investigations. She also has a strong interest in the use of novel non-invasive imaging techniques to predict fracture risk and monitor response to osteoporosis therapies. Dr. Bouxsein serves on the committee of scientific advisors for the International Osteoporosis Foundation, is a board member of the International Bone and Mineral Society, was co-editor of the Osteoporosis International Supplement on Bone Quality, and was a co-organizer of the NIH/ASBMR-sponsored workshop on Bone Quality. In 2005, she received the Fuller Albright Award from the American Society of Bone and Mineral Research, awarded annually in recognition of meritorious scientific contributions by a young investigator. Dr. Bouxsein has published over 80 peer-reviewed articles and 20 book chapters.

Recent Publications

Riggs BL, Melton LJ, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, Rouleau PA, McCollough CH, Bouxsein ML, Khosla S. Population-based study of age and sex differences in bone volumetric density, size, geometry and structure at different skeletal sites. J Bone Min Res 2004; 19:1945-54.

Bouxsein ML, Pierroz D, Glatt V, Goddard DS, Cavat F, Rizzoli R, Ferrari SL. Beta-arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice. J Bone Min Res, 2005; 20:635-43.

Ferrari SL, Pierroz DD, Glatt V, Goddard DS, Bianchi EN, Lin FT, Manen D, Bouxsein ML. Bone response to intermittent parathyroid hormone is altered in mice null for ß-arrestin2. Endocrinology 2005; 146:1854-1862.

Bouxsein ML, Myers KS, Shultz KL, Donahue LR, Rosen CJ, Beamer WJ. Ovariectomy-induced bone loss varies among inbred strains of mice. J Bone Min Res 2005; 20 (7): 1085-92.

Boutroy S, Bouxsein ML, Munoz F, Delmas PD. In vivo assessment of trabecular microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrin & Metab 2005; 90 (12): 6508-15.

Riggs BL, Melton LJ, Robb RA, Camp JJ, Atkinson EJ, Oberg A, Rouleau PA, McCollough CH, Khosla S, Bouxsein ML. Population based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures. J Bone Min Res 2006; 21:315-23.

Pierroz DP, Bouxsein ML, Rizzoli R, Ferrari SL. Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice. Bone 2006; 39 (2): 260-7.

Viguet-Carrin S, Roux JP, Arlot ME, Merabet Z, Leeming J, Byrjalsen I, Delmas PD, Bouxsein ML. Contribution of the advanced glycation endproduct pentosidine and maturation of the collagen to compressive biomechanical properties of human lumbar vertebrae. Bone 2006; 39 (5): 1073-9.

Bouxsein ML, Riggs BL, Melton LJ III, Muller JA, Atkinson EJ, Oberg A, Robb RA, Camp JJ, Rouleau PA, McCollough CH, Khosla S. Biomechanical assessment of the age- and sex-related differences vertebral fragility: A population-based study using QCT. J Bone Min Res 2006; 21 (9): 1475-82.

Liu X, Bruxvoort KJ, Zylstra CR, Liu J, Cichowski R, Faugere M-C, Bouxsein ML, Wan C, Williams BO, Clemens TL. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proc Natl Acad Sci 2007; 104 (7): 2259-64.

Bouxsein ML, Szulc P, Munoz F, Thrall E, Sornay-Rendu E, Delmas PD. Contribution of trochanteric soft tissues to fall force estimates, the factor of risk, and prediction of hip fracture. J Bone Min Res 2007: 22(6): 25-31.

Wang Y, Wan C, Liu X, Cao X, Bouxsein ML, Faugere M-C, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL (2007) The hypoxia-inducible factor pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest 2007; 117(6):1616-26.

Glatt V, Canalis E, Stadmeyer L, Bouxsein ML. Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Min Res 2007; 22 (8): 1197-1207.

Melton LJ, Riggs BL, van Lenthe GH, Achenbach SJ, Muller R, Bouxsein ML, Amin S, Atkinson EJ, Khosla S. Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women. J Bone Min Res 2007; 22(9): 1442-8.

Kostenuik P, Ferrari S, Pierroz D, Bouxsein ML, Morony S, Warmington KS, Adamu S, Geng Z, Grisanti M, Shalhoub V, Martin S, Biddlecome G, Shimamoto G, Boone T, Shen V.Lacey D. Infrequent delivery of a long-acting PTH-Fc fuion protein has potent anabolic effects on cortical and cancellous bone. J Bone Min Res 2007; 22 (10): 1534-47.

Melton LJ, Riggs BL, Keaveny TM, Achenbach SJ, Hoffman PF, Camp JJ, Rouleau PA, Bouxsein ML, Amin S, Atkinson EJ, Robb RA, Khosla S. Structural determinants of vertebral fracture risk. J Bone Min Res 2007 (in press).

Boutroy S, van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD. Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Min Res (in press)

Reviews, Chapters, and Editorials:

Bouxsein ML. Determinants of Skeletal Fragility. In Best Practice & Research, Clinical Rheumatology. Ed: D. Reid and P. Geusens, Rapid Medical Media, Eastbourne, East Sussex, UK; 2005, 19(6): 897-912.

Rosen CJ, Bouxsein ML. Is osteoporosis obesity of bone? Nature Clinical Practice Rheumatology; 2006: 2: 1-9.

Bouxsein ML and Karasik D. Bone geometry and skeletal fragility. Current Osteoporosis Reports; 2006: 4 (4): 49-56.

Bouxsein ML. Biomechanics of osteoporotic fractures. Clinical Reviews in Bone and Mineral Metabolism, 2006; 4 (3): 143-54.

Bouxsein ML. Biomechanics of Age-Related Fractures. In Osteoporosis IIIe. ed: R Marcus, J Kelsey, C Rosen and D Feldman, Academic Press, Inc., San Diego; 2007, p 601-616

Marcus R and Bouxsein ML. The Nature of Osteoporosis. In Osteoporosis IIIe. ed: R Marcus, J Kelsey, C Rosen and D Feldman, Academic Press, Inc., San Diego; 2007, p 27-33.